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CASE SERIES
Year : 2016  |  Volume : 13  |  Issue : 3  |  Page : 145-149

Mixed gonadal dysgenesis in Yaoundé: A preliminary experience about three cases


1 Pediatric Sugery Service, Gyneco Obstetric and Paediatric Hospital, Yaoundé, Cameroon
2 University Teaching Hospitals of Geneva, Geneva, Switzerland
3 Department of Surgery and Subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon
4 Lyon Teaching Hospital, Lyon, France

Correspondence Address:
F F Mouafo Tambo
Pediatric Sugery service, Gyneco-Obstetric and Paediatric Hospital, P. O. Box 5790, Yaounde
Cameroon
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0189-6725.187822

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Mixed gonadal dysgenesis is characterised by unilateral chromosomal abnormality, which is probably the result of anaphase lag during mitosis. The 45, XO/46, XY karyotype is the most common form of mosaicism involving the Y chromosome. It is a rare clinical entity with a worldwide incidence of 1.5/10,000 live births. Its epidemiology in Sub-Saharan Africa is not known. This study reports experience in the management of 3 cases at the Yaounde Gynecologic-Obstetric and Paediatric Hospital. From November 2009 to November 2014, 3 cases were successfully managed at our institution. Results: All patients presented with asymmetrical gonadal differentiation. On one side of the body, a poorly-developed testicular gonad and on the other side a gonadal streak. A persistent Mόllerian remnant was equally found in the 3 cases. Management of mixed gonadal dysgenesis should be done in tertiary health care centres. A multidisciplinary team approach is recommended.


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