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Investigation of serum interleukin 6, high-sensitivity C-reactive protein and white blood cell levels during the diagnosis and treatment of paediatric appendicitis patients before and during the COVID-19 pandemic


1 Department of Paediatric Surgery, Inonu University, Malatya, Turkiye
2 Department of Bioistatistics, Faculty of Medicine, Erciyes University, Kayseri, Turkiye
3 Department of Paediatrics, Inonu University, Malatya, Turkiye
4 Department of Anaesthesiology, Inonu University, Malatya, Turkiye
5 Department of Pathology, Inonu University, Malatya, Turkiye
6 Department of Biostatics and Medical Informatics, Faculty of Medicine, Inonu University, Malatya, Turkiye

Correspondence Address:
Kubilay Gürünlüoglu,
Department of Paediatric Surgery, Faculty of Medicine, Inonu University, Malatya
Turkiye
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajps.ajps_128_21

Introduction: In this study, we prospectively investigated changes in serum interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and full white blood cell (WBC) counts during the diagnosis and treatment of paediatric patients with appendicitis. We also investigated the effects of the COVID-19 pandemic on the diagnosis and treatment processes of paediatric appendicitis patients. Materials and Methods: A non-perforated appendicitis group (n = 110), a perforated appendicitis group (n = 35) and an appendicitis + COVID-19 group (n = 8) were formed. Blood samples were taken upon admission and every day until the three studied parameters returned to normal values. To investigate the effects of the COVID-19 pandemic on paediatric appendicitis patients, the perforated appendicitis rates and the times from the onset of the first symptoms to the operation before and during the pandemic were compared. Results: WBC, IL-6, and hsCRP dropped below the upper limits on the second postoperative day in the non-perforated appendicitis group, four to six days postoperatively in the perforated appendicitis group, and three to six days postoperatively in the appendicitis + COVID-19 group. These parameters were not within normal range in patients who developed complications during follow-up. The time from the onset of abdominal pain to the surgery was significantly longer during than before the pandemic in both the non-perforated appendicitis group and the perforated appendicitis group. Conclusions: Our results show that WBC, IL-6, and hsCRP are useful laboratory parameters that can complete clinical examinations in the diagnosis of appendicitis in paediatric patients and the identification of complications that may develop postoperatively.


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    -  Gürünlüoglu K
    -  Zararsiz G
    -  Aslan M
    -  Akbas S
    -  Tekin M
    -  Gürünlüoglu S
    -  Gözükara Bag H
    -  Cin ES
    -  Macit B
    -  Demircan M
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